abstract：:Diabetes and heart failure (HF) are both global epidemics with tremendous costs on society with increased rates of HF hospitalizations and worsened prognosis when co-existing, making it a significant "deadly duo." The evidence for pharmacological treatment of HF in patients with type 2 diabetes mellitus (T2DM) stems t...

journal_title：Heart failure reviews

authors： Ofstad AP,Atar D,Gullestad L,Langslet G,Johansen OE

更新日期：2018-05-01 00:00:00

abstract：:Diabetes mellitus is a chronic disease requiring lifelong control with hypoglycemic agents that must demonstrate excellent efficacy and safety profiles. In patients taking glucose-lowering drugs, hypoglycemia is a common cause of death associated with arrhythmias, increased thrombus formation, and specific effects of ...

journal_title：Heart failure reviews

authors： Anfinogenova Y,Grakova EV,Shvedova M,Kopieva KV,Teplyakov AT,Popov SV

更新日期：2018-05-01 00:00:00

abstract：:Heart failure (HF) is a common complication in patients with type 2 diabetes and it is closely associated with high morbidity and mortality rate. The incidence of cardiovascular events in patients with diabetes is related to high levels of glycemia, expressed by increase of HbA1c levels. However, there is little evide...

journal_title：Heart failure reviews

authors： Palazzuoli A,Ceccarelli E,Ruocco G,Nuti R

更新日期：2018-05-01 00:00:00

abstract：:Diabetes is a global epidemic and a leading cause of death with more than 422 million patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel and effective drugs in managing glycemia of T2D patients. These inhibitors gained...

journal_title：Heart failure reviews

authors： Kaplan A,Abidi E,El-Yazbi A,Eid A,Booz GW,Zouein FA

更新日期：2018-05-01 00:00:00

abstract：:Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...

journal_title：Heart failure reviews

authors： Ruggeri C,Gioffré S,Achilli F,Colombo GI,D'Alessandra Y

更新日期：2018-01-01 00:00:00

abstract：:The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in r...

journal_title：Heart failure reviews

authors： Singh RM,Waqar T,Howarth FC,Adeghate E,Bidasee K,Singh J

更新日期：2018-01-01 00:00:00

abstract：:To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the f...

journal_title：Heart failure reviews

authors： Krueger K,Griese-Mammen N,Schubert I,Kieble M,Botermann L,Laufs U,Kloft C,Schulz M

更新日期：2018-01-01 00:00:00

abstract：:Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarct...

journal_title：Heart failure reviews

authors： Pereira RM,Mekary RA,da Cruz Rodrigues KC,Anaruma CP,Ropelle ER,da Silva ASR,Cintra DE,Pauli JR,de Moura LP

更新日期：2018-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they al...

journal_title：Heart failure reviews

authors： Petta V,Perlikos F,Loukides S,Bakakos P,Chalkias A,Iacovidou N,Xanthos T,Tsekoura D,Hillas G

更新日期：2017-11-01 00:00:00

abstract：:There is substantial causal and consequential interaction between the ever-growing heart failure and renal failure patients. Half of the patients with heart failure (HF) have preserved left ventricular ejection fraction (HFpEF), which is difficult to diagnose and rising in prevalence relative to HF with reduced EF (HF...

journal_title：Heart failure reviews

authors： Afsar B,Rossignol P,van Heerebeek L,Paulus WJ,Damman K,Heymans S,van Empel V,Sag A,Maisel A,Kanbay M

更新日期：2017-11-01 00:00:00

abstract：:Ischemic heart disease (IHD) remains the single most common cause of death worldwide. Ischemic cardiomyopathy is a major sequel of coronary artery disease. The economic health burden of IHD is substantial. In patients with old myocardial infarction (OMI), the extent of viable myocardium (VM) directly affects the short...

journal_title：Heart failure reviews

authors： Jamiel A,Ebid M,Ahmed AM,Ahmed D,Al-Mallah MH

更新日期：2017-07-01 00:00:00

abstract：:Cardiac magnetic resonance spectroscopy (MRS) is a noninvasive method to assess by-products of myocardial metabolism. Recent developments in shorter scan protocols and more powerful field strengths have created interest in utilizing this technology in studying and characterizing the metabolic derangements in heart fai...

journal_title：Heart failure reviews

authors： Qureshi WT,Nasir UB

更新日期：2017-07-01 00:00:00

abstract：:Evidence-based management has improved long-term survival in patients with heart failure (HF). However, an unintended consequence of increased longevity is that patients with HF are exposed to a greater symptom burden over time. In addition to classic symptoms such as dyspnea and edema, patients with HF frequently suf...

journal_title：Heart failure reviews

authors： Alpert CM,Smith MA,Hummel SL,Hummel EK

更新日期：2017-01-01 00:00:00

abstract：:Predictive computational modelling in biomedical research offers the potential to integrate diverse data, uncover biological mechanisms that are not easily accessible through experimental methods and expose gaps in knowledge requiring further research. Recent developments in computing and diagnostic technologies have ...

journal_title：Heart failure reviews

authors： Sack KL,Davies NH,Guccione JM,Franz T

更新日期：2016-11-01 00:00:00

abstract：:There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially im...

journal_title：Heart failure reviews

authors： Mikhailov AT,Torrado M

更新日期：2016-11-01 00:00:00

abstract：:Stem cell therapy is a promising approach to the treatment of ischemic heart disease via replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials have indicated that cardiac function improved consistently, but very modestly after cell-based therapy. This mainly attributed to low...

journal_title：Heart failure reviews

authors： Huang P,Tian X,Li Q,Yang Y

更新日期：2016-11-01 00:00:00

abstract：:Ultrafiltration (UF) has emerged as an alternative therapy for acute decompensated heart failure (ADHF) due to its physiological benefits such as improvement in neurohormonal activation. We performed a systematic review and a meta-analysis to evaluate the efficacy, safety, and the impact on outcomes for UF therapy as ...

journal_title：Heart failure reviews

authors： Jain A,Agrawal N,Kazory A

更新日期：2016-09-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a subcategory of pulmonary hypertension (PH) that comprises a group of disorders with similar pulmonary vascular pathology. Though PH is common, the estimated incidence of IPAH is 1-3 cases per million, making it a rare disease. The hemodynamic definition of PAH is a mean pulmo...

journal_title：Heart failure reviews

authors： Awdish R,Cajigas H

更新日期：2016-05-01 00:00:00

abstract：:Pulmonary hypertension that develops in the setting of underlying lung diseases such as COPD or idiopathic pulmonary fibrosis (IPF) is associated with decreased functional status, worsening hypoxemia and quality of life, and increased mortality. This complication of lung disease is complex in its origin and carries a ...

journal_title：Heart failure reviews

authors： Cuttica MJ

更新日期：2016-05-01 00:00:00

abstract：:Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest act...

journal_title：Heart failure reviews

authors： Folino A,Montarolo PG,Samaja M,Rastaldo R

更新日期：2015-07-01 00:00:00

abstract：:Right ventricular (RV) diastolic dysfunction was first reported as an indicator for the assessment of ventricular dysfunction in heart failure a little over two decades ago. However, the underlying mechanisms and precise role of RV diastolic dysfunction in heart failure remain poorly described. Complexities in the str...

journal_title：Heart failure reviews

authors： Axell RG,Hoole SP,Hampton-Till J,White PA

更新日期：2015-05-01 00:00:00

abstract：:It is well established that cardiac remodeling plays a pivotal role in the development of heart failure, a leading cause of death worldwide. Meanwhile, sympathetic hyperactivity is an important factor in inducing cardiac remodeling. Therefore, an in-depth understanding of beta-adrenoceptor signaling pathways would hel...

journal_title：Heart failure reviews

authors： Yang J,Liu Y,Fan X,Li Z,Cheng Y

更新日期：2014-11-01 00:00:00

abstract：:The pathophysiology of heart failure (HF) is characterized by an abnormal activation of neurohumoral systems, including the sympathetic nervous and the renin-angiotensin-aldosterone systems, which have long-term deleterious effects on the disease progression. Perpetuation of this neurohumoral activation is partially d...

journal_title：Heart failure reviews

authors： Sousa-Pinto B,Ferreira-Pinto MJ,Santos M,Leite-Moreira AF

更新日期：2014-11-01 00:00:00

abstract：:Cardiopulmonary exercise testing (CPET) is a procedure widely used in daily clinical activity to investigate cardiac and pulmonary disorders. Peak oxygen consumption (VO2 peak) is the most validated and clinically accepted parameter used to report aerobic capacity in healthy individuals and in different clinical setti...

journal_title：Heart failure reviews

authors： Gargiulo P,Olla S,Boiti C,Contini M,Perrone-Filardi P,Agostoni P

更新日期：2014-09-01 00:00:00

abstract：:From previous systematic reviews and meta-analyses, there is consensus about the positive effect of exercise training on exercise capacity for systolic heart failure (HF); however, the effect on actual prognostic markers such as NTproBNP and minute ventilation/carbon dioxide production (VE/VCO2) slope has not been eva...

journal_title：Heart failure reviews

authors： Cipriano G Jr,Cipriano VT,da Silva VZ,Cipriano GF,Chiappa GR,de Lima AC,Cahalin LP,Arena R

更新日期：2014-09-01 00:00:00

abstract：:Chronic heart failure (CHF) is a multi-dimensional and complex syndrome. Outcome measures are important for determining both the efficacy and quality of care and capturing the patient's perspective in evaluating the outcomes of health care delivery. Capturing the patient's perspective via patient-reported outcomes is ...

journal_title：Heart failure reviews

authors： Chang S,Newton PJ,Inglis S,Luckett T,Krum H,Macdonald P,Davidson PM

更新日期：2014-03-01 00:00:00

abstract：:Despite therapeutic advances, patients with worsening heart failure (HF) requiring hospitalization have unacceptably high post-discharge mortality and re-admission rates soon after discharge. Evidence suggests a hypercoagulable state is present in patients with HF. Although thromboembolism as a direct consequence of H...

journal_title：Heart failure reviews

authors： Gheorghiade M,Vaduganathan M,Fonarow GC,Greene SJ,Greenberg BH,Liu PP,Massie BM,Mehra MR,Metra M,Zannad F,Cleland JG,van Veldhuisen DJ,Shah AN,Butler J

更新日期：2013-11-01 00:00:00

abstract：:The heart consumes huge amounts of energy to fulfil its function as a relentless pump. A highly sophisticated system of energy generation based on flexibility of substrate use and efficient energy production, effective energy sensing and energy transfer ensures function of the healthy heart across a range of physiolog...

journal_title：Heart failure reviews

authors： Siddiqi N,Singh S,Beadle R,Dawson D,Frenneaux M

更新日期：2013-09-01 00:00:00

abstract：:Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure...

journal_title：Heart failure reviews

authors： Zizola C,Schulze PC

更新日期：2013-09-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) is the only non-invasive, non-radiation-based technique for investigating the metabolism of living tissue. MRS of protons (1H-MRS), which provides the highest sensitivity of all MR-visible nuclei, is a method capable of detecting and quantifying specific cardiac biomolecules, such...

journal_title：Heart failure reviews

authors： Faller KM,Lygate CA,Neubauer S,Schneider JE

更新日期：2013-09-01 00:00:00

abstract：:Descriptions of the pathophysiology of heart failure have gone through a substantial evolution in the last 50 years. It is now recognised that heart failure can occur in the presence and also in the absence of a reduction in left ventricular function. In the former situation, this classically has been described to lea...

journal_title：Heart failure reviews

authors： Dorhout Mees EJ

更新日期：2013-07-01 00:00:00

abstract：:Heart failure continues to be associated with high morbidity and mortality. Over the past decade, left ventricular assist devices have been shown to improve the survival and quality of life. However, it is quite clear that very sick patients do not do as well, and it is therefore imperative to select patients at the p...

journal_title：Heart failure reviews

authors： Gilotra NA,Russell SD

更新日期：2013-01-01 00:00:00

abstract：:Despite remarkable progress in the therapeutic approach of patients with chronic heart failure (CHF), exercise intolerance remains one of the hallmarks of the disease. During the past two decades, evidence has accumulated to underscore the key role of both endothelial dysfunction and skeletal muscle wasting in the pro...

journal_title：Heart failure reviews

authors： Conraads VM,Van Craenenbroeck EM,De Maeyer C,Van Berendoncks AM,Beckers PJ,Vrints CJ

更新日期：2013-01-01 00:00:00

abstract：:Many factors contribute to the pathophysiology and progression of heart failure (HF), offering the potential for many synergistic therapeutic approaches to its management. For patients, who have systolic HF, prolonged QRS and receiving guideline-indicated pharmacological therapy, cardiac resynchronization therapy (CRT...

journal_title：Heart failure reviews

authors： Buga L

更新日期：2012-11-01 00:00:00

abstract：:Important changes occur in the cardiovascular system with advancing age, even in apparently healthy individuals. Thickening and stiffening of the large arteries develop due to collagen and calcium deposition and loss of elastic fibers in the medial layer. These arterial changes cause systolic blood pressure to rise wi...

journal_title：Heart failure reviews

authors： Fleg JL,Strait J

更新日期：2012-09-01 00:00:00

abstract：:Significant growth in the elderly population (age ≥ 65 years) with heart failure (HF) has taken place in developed countries and is occurring in most developing countries. Projections from population studies in the United States, Europe and other developed countries suggest that this trend will very likely continue an...

journal_title：Heart failure reviews

authors： Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Although several risk factors including hypertension, cardiac hypertrophy, coronary artery disease, and diabetes are known to result in heart failure, elderly subjects are more susceptible to myocardial infarction and more likely to develop heart failure. This article is intended to discuss that cardiac dysfunction in...

journal_title：Heart failure reviews

authors： Dhalla NS,Rangi S,Babick AP,Zieroth S,Elimban V

更新日期：2012-09-01 00:00:00

abstract：:The aging population with hypertension and coronary artery disease is rapidly increasing worldwide and develops heart failure (HF). A wide range of pharmacotherapeutic drugs are recommended in the HF management guidelines. For the most part, these recommendations are based on the results of studies in the younger popu...

journal_title：Heart failure reviews

authors： Man JP,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...

journal_title：Heart failure reviews

authors： Butler CR,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a common debilitating condition with limited therapeutic options besides heart transplantation or palliation. It is characterized by maladaptive remodeling of cardiomyocytes, extracellular collagen matrix (ECCM) and left ventricular (LV) geometry which contributes to further dysfunction...

journal_title：Heart failure reviews

authors： Butler CR,Jugdutt BI

更新日期：2012-09-01 00:00:00